These nonsmoking hotel guests got charged smoking fees The Points Guy Can I Vape In A Hotel Room? Vapor Shop Direct Can Vaping Set Off a Smoke Alarm? Here's What You Need to Know Do Vapes Set Off Smoke Alarms? What You Should Know Your guests aren't the only ones checking in. So are their vape pens. With over 13 million regular vapers in the U.S. alone, unauthorized vaping is a major operational risk for hotels. Can hotels detect vaping in rooms?